PGT-A: preimplantation genetic test

By May 10, 2022 PGT, Treatment
PGT-A Test

What is the PGT-A test?

It is a genetic test performed on a day 5 embryo (blastocyst).
Some cells are taken from the blastocyst, and then the blastocyst is frozen (it will wait until the test results are back to be transferred to the mother)
These cells contain the genetic material of the embryo and will confirm if it is genetically healthy or not. The results take around three weeks.
When the results come back, they will show if the embryo is genetically viable and can be transferred. If so, the patient will undergo an endometrial preparation treatment to transfer the tested healthy embryo.

Why is it needed?

Genetic alterations in the embryos are not rare, it is just something that happens (in assisted reproduction treatments, but also in natural pregnancies) and that can lead to early miscarriages. Therefore, this test is performed to avoid transferring an embryo with a genetic alteration that would likely result in an unsuccessful pregnancy.

When is it Needed?

The PGT-A test is recommended when the maternal or paternal age is advanced, as the genetic alterations in the gametes increase with age.
It is nevertheless an option in all IVF treatments if patients want to ensure that the embryo they are transferring is genetically viable.

How does it work?

The patient will go through an IVF process or an egg donation, the eggs will be retrieved and fertilised, and the embryos created in the lab. Once they reach the blastocyst stage (day 5), a tiny sample will be taken from them (this does not damage the embryos) to analyse their genetics.

The patient won’t undergo any other treatment while waiting for the results (it is necessary to make sure that the embryos are genetically viable before transferring).

The endometrial preparation of the patient will start once the results are back and confirm that there is a viable embryo. It will be a frozen embryo transfer, as the embryo needed to be frozen while the PGT-A samples were being analysed. There might be more than one viable embryo, in which case the one(s) not transferred will remain frozen for the future. The embryos that show genetic abnormalities cannot be transferred, as they would lead to miscarriages or unhealthy babies.

The patient takes medication for the endometrial preparation (oestrogen to thicken the endometrium) for around 10-12 days. Then, she’ll have an ultrasound around day 10-12 to ensure that the endometrium is thick enough to allow implantation (around 7mm) and that she has not ovulated (sometimes an extra medication is administered to avoid spontaneous ovulation). If everything is fine, she’ll continue with oestrogen and start taking progesterone (generally vaginal pessaries) 5 days before the transfer.

The tested embryo will be transferred then, and with a bit of luck, the process will lead to a healthy pregnancy.

Is PGT-A included in Redia IVF’s Refund Guarantee Programmes?

PGT-A is always a possibility.
It is indeed included in the first cycle of our Combined Programme, which is done using the patient’s own eggs. It is not compulsory for the second and third cycle, as we would use an egg donation, but it is possible to include it.

If patients wish to include PGT-A in their programme -IVF, egg donation, ROPA or the second half of the Combined Programme- it can be added with an extra cost, and it becomes refundable. This means that the cost of the PGT-A will be included in the total price of the programme, and it will be performed in every cycle; if at the end of the third cycle there’s no live birth, the whole amount, including the extra paid for the PGT-A, will be refunded.
As an alternative, patients can choose to pay the PGT-A directly to their clinic, in which case it wouldn’t be part of the programme, and therefore would not be refunded back with the programme cost if at the end of the third cycle there is not a live birth.

Redia IVF’s main objective is to make sure that patients have a programme perfectly tailored for their needs and preferences. We adapt to your wishes, and make sure that the process is as easy and enjoyable as possible. We know your goal is to have your baby at home, and we work with our partner clinics in order to achieve it as soon as possible, always guaranteeing the highest quality and patient care.

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